Some patients may experience other side effects that are not listed here. This is not a complete list of side effects. What are the most common side effects of treatment with Praxbind? How is Praxbind typically given (administered)? Praxbind is given as an infusion into a vein. This allows thrombin to resume its role in the coagulation process in blood cells. Praxbind binds with Pradaxa with higher affinity than the Pradaxa does to the thrombin. Thrombin is a key element in the coagulation process. What is the mechanism of action? Praxbind is a monoclonal antibody made to reverse Pradaxa, a compound that directly blocks thrombin. VKA, vitamin K antagonist.For which conditions is this drug approved? Praxbind® is indicated for patients specifically treated with Pradaxa® (dabigatran etexilate mesylate), an anti-clotting agent, when reversal of the anti-clotting effects of the agent is needed for emergency procedures, life-threatening instances, or uncontrolled bleeding.
Prevention of adverse outcomes after acute management of ACS with increased biomarkersĬHA 2DS 2 VASc, congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischaemic attack (doubled), vascular disease, age 65–74, female TIA, transient ischaemic attack (range 0-9). Possible treatment in specific circumstances Stroke and systemic embolism prevention in patients with non-valvular AF Secondary prevention or management of DVT or PE VTE prevention after elective hip or knee replacement NICE accepts no responsibility for the use of its content in this product/publication Indication All NICE guidance is subject to regular review and may be updated or withdrawn. NICE guidance is prepared for the National Health Service in England. Anticoagulants, including non-vitamin K antagonist oral anticoagulants (NOACs). Reviewer Acknowledgement 2018 to January 2023ĪCS, acute coronary syndrome DVT, deep vein thrombosis NICE, National Institute for Health and Care Excellence PE, pulmonary embolism.
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